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The market size for both is in the hundreds of millions and growing fast. There's good reason for this
Bi-allelic variants in COL3A1 encoding the ligand to GPR56 are associated with cobblestone-like cortical malformation, white matter changes and cerebellar cysts
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Accordingly, the metabolic consequences of GLP-1RA therapy cannot be inferred solely from improvements in inflammatory tone or glycemic control
It warns that the full benefit will only be realised if uptake is high, patients stay on treatment long term and lifestyle changes support weight loss
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