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Options for managing tolerance include a brief dose reduction for 4 to 8 weeks ("drug holiday" at a lower dose, not complete cessation), lifestyle optimization to maximize the medication effect, evaluation for other contributing factors (thyroid function, cortisol, sleep quality, medication interactions), and consideration of adding a complementary compound to address specific aspects of the plateau

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Consistency in administration remains more important than the specific quantity per dose

Liraglutide was approved by the FDA under the name Victoza in 2010 to treat adults with type 2 diabetes and as Saxenda in 2014 for weight loss