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However, in clinical trials, the significant weight loss brought about by GLP-1RAs is usually accompanied by an absolute decrease in fat-free body mass or skeletal muscle mass [55]

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Using 1:1 propensity matching, researchers compared 1,101 GLP-1 RA users with 1,101 non-users, matched by demographics, comorbidities, and medication history

They found that a huge amount of physiological regulation happens not through large hormones alone, but through these shorter signaling sequences