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Creatine monohydrate as adjunctive treatment in people with bipolar depression showed a significant improvement in verbal fluency compared with placebo, but not on other neuropsychological tests [64]

People with dietary restrictions, high-stress lifestyles, or metabolic challenges often see significant improvements in energy levels, mental clarity, and overall vitality

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Patients and providers should treat them as directional rather than definitive, and decisions about participating in trials or accessing investigational therapies should always involve a specialist in endocrinology or metabolic medicine.

Studies have examined the implications of altered methylation patterns for gene expression and cellular function