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Overall, HT pathogenesis results from a complex interplay between innate and adaptive immunity, where breakdowns in tolerance, skewed Th1/Th17/Treg balance, and persistent autoantibody production sustain chronic inflammation and irreversible thyroid destruction

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Pioglitazone (Actos) Pioglitazone, a thiazolidinedione, activates PPAR-gamma receptors to improve insulin sensitivity in muscle, liver, and adipose tissue