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The key insulinotropic actions of GLP-1 via the class B1 G-protein-coupled receptor (GPCR) are exerted by cyclic adenosine monophosphate (cAMP) formation, which, in conjunction with increased Ca 2+ levels, promotes exocytosis of insulin-containing vesicles [39]

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In 1879, a chemist named Constantin Fahlberg sat down to dinner without washing his hands after a day spent handling coal tar

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