Aronne LJ, Wadden TA, Peterson C, Winslow D, Odeh S, Gadde KM
Mechanistic evidence from animal models requires validation in human interventional studies before therapeutic targeting can be recommended

By leveraging berberine's documented ability to influence cellular energy regulation and glucose metabolism, this botanical product is positioned as an accessible, scientifically backed holistic alternative to naturally manage blood sugar levels and support sustainable wellness without relying solely on synthetic pharmaceuticals In December 2025, Innovent Biologics, a world-class biopharmaceutical company that develops, manufactures and commercializes high-quality medicines for the treatment of oncologic, autoimmune, cardiovascular and metabolic, ophthalmologic and other major diseases, announces that the results of two Phase III clinical studies of Mazdutide, the world's first approved glucagon (GCG)/glucagon-like peptide-1 (GLP-1) dual receptor agonist, in Chinese adults with type 2 diabetes (T2D) (DREAMS-1, DREAMS-2) have been published back-to-back in Nature as Accelerated Article Previews (AAP)

Differential response of wheat genotypes to long term salinity stress in relation to oxidative stress, antioxidant activity and osmolyte concentration
Doxorubicine-Congestive Heart Failure-Increased Big Endothelin-1 Plasma Concentration: Reversal by Amlodipine, Losartan, and Gastric Pentadecapeptide BPC157 in Rat and Mouse