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This results in a reduction in the number of TH-positive neurons and dopamine content, thereby exacerbating dopaminergic neuronal damage in PD mice

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However, the endothelial damage observed in ME/CFS patients does not appear to correlate with the usual markers of endothelial dysfunction seen in cardiovascular disease such as increased levels of symmetric dimethylarginine (SDMA), asymmetric dimethylarginine (ADMA), and high-sensitivity C-reactive protein (hs-CRP), and reduced levels of arginine and homoarginine (311)

While generally safe, they can cause side effects such as nausea and diarrhea, which typically diminish over time