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80% (95% CI 64, 96) of CKD risk
The vitamin D RDA is 600 IU/day for adults up to 70 and 800 IU/day above 70, with a tolerable upper limit of 4,000 IU (NIH Office of Dietary Supplements)
The index single-nucleotide polymorphism (SNP) of the main association was rs10305420 ( P = 2.9 10 10 , reference allele C, effect allele T), which conferred an additional 0.641% BMI loss per T allele, approximately equivalent to an additional 0.76 kg weight loss per allele (95% CI, [1.27, 0.34] kg)
Its utility in off-label psychiatric applications continues to evolve
The SELECT trial, published in the New England Journal of Medicine , found that semaglutide, known by the brand name Ozempic, significantly reduced the risk of heart attacks and strokes in people with obesity and established cardiovascular disease
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