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Both are GLP-1 receptor agonists (falling under S2), and both are relatively new drugs that would also be covered by the S0 non-approved substance rule

Approximately 25% of total weight lost on tirzepatide was lean mass (SURMOUNT-1 DXA substudy), and in semaglutide trials, that proportion may reach up to 40% (STEP 1 DXA subset)

Recent studies suggest that Semaglutide can also offer significant benefits for mental health, especially for individuals struggling with anxiety, depression, and stress related to obesity and chronic conditions

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