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Their data cannot determine whether the differences reflect biology, access to care, treatment persistence, dose escalation, social conditions, or other factors not captured in the analysis

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1 Contraindications or require Caution: individuals who are pregnant or breastfeeding, have a history of cancer, or have pre-existing liver or kidney conditions

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1 9 10 But animal efficacy translating to human benefit is the exception, not the rule, in drug development