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In such cases, specific binding is identified by reduction of enrichment in the presence of the parent compound
10.1038/nm873
Top candidates included anti-SLA, a well-recognized autoantibody in AIH, as well as antibodies targeting a linker region of the relaxin family peptide receptor 1 (RXFP1), which is required for receptor activation
This provides a path forward for those who cannot access or afford branded options but still require medical support
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