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Based on our data, we propose that T3 has a regulatory role in insulin-controlled glucose metabolism, and T3 exerts this function by increasing non-12-OH FXR-antagonistic BA levels via downregulating the expression of CYP8B1, which potentiates GLP-1 production via suppressing the intestinal FXR signaling

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Clinical trials have observed that the application of the peptide IGF-1LR3 has a positive effect in treating certain types of cancer, type 2 diabetes, and muscular dystrophy

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Lancet 2022;400:1788-801.PubMedPMC 60