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Last medically reviewed: 2026-04-27 by GLP3 Planner editorial

3.3 Modulating CAFs and ECM CAFs contribute to immunotherapy resistance through multiple mechanisms, including physical barrier formation, secretion of immunosuppressive cytokines, and metabolic reprogramming of the TME (34)

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Shed also offers brand-name Zepbound, which provides a transition path if compounded options become unavailable