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Like GSTP, GSTM1 interacts with its partner in the absence of oxidative stress, although ASK1 is also involved in heat shock response, which is likewise prevented during ASK1 sequestration
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Strategies such as delaying therapy until after pubertal onset or implementing short-term discontinuation have been proposed but remain experimental and require rigorous validation
Nail growth is typically the earliest visible sign (within the first month), followed by improved skin elasticity and hair quality over 36 months
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