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However, the side effects are not predictable and anyone can suffer at any time, while some people may not face any problems at all

Pain disrupts sleep, and poor sleep amplifies pain perception, creating a vicious cycle that DSIP may help break

When oxygen and transporter capacity are sufficient, it serves as an oxidative fuel and signaling molecule for neurons, through astrocyte-neuron lactate shuttling [11, 12]

For the purpose of this review, separate MMRM analyses were performed for the three phase 3a SCALE trials [38] and, in general, the treatment effects estimated using the MMRM analysis method were larger than those estimated using LOCF (Table 2)

Klicek R et al