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Symptoms may be more noticeable when treatment starts or when doses change, but dose decisions should stay with the prescriber
Campos, C
Standard / Gradual Approach The escalation used in REDEFINE mirrors the standard semaglutide ladder, applied to both peptides at once: start at 0.25 mg of each per week and roughly double the step every four weeks toward a 2.4 mg + 2.4 mg weekly target [1]
doi: 10.1016/j.ejphar.2009.12.023 115 CastellanaMCignarelliABresciaFPerriniSNatalicchioALaviolaLet al
Some specialists recommend repeat liver imaging to document reduction in hepatic steatosis, though this is not universally required
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