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In REDEFINE 1, adults with obesity or overweight (without diabetes) treated with CagriSema had a mean body weight reduction of 20.4% at 68 weeks under the treatment-policy estimand, compared with 3.0% on placebo

11 of these 12 patients reported improvement in their symptoms after telephone follow up

To determine whether these changes in gene and protein expression led to a functional disruption of the tight junction, immunofluorescence against claudin-5 was performed, demonstrating staining localized to the cell membrane of basal cells

A standard working concentration is 1mg/mL (0.1%): add 10mL to a 10mg vial