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Longer treatment/follow-up amplifies it

Total DNA was extracted with Genomic DNA Isolation Kit (Norgen Biotek Corp., Thorold, Ontario, Canada), according to the manufacturers protocol

Another study found that tirzepatide increased the time it took the ethinylestradiol to be fully absorbed into the bloodstream from two to four hours, which could be due to the drugs effect of slowing stomach emptying because ethinylestradiol is mostly absorbed in the small intestine

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The difference appears to correlate with baseline insulin resistance: patients with higher HOMA-IR scores at baseline show more pronounced plateaus