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Los hitos relevantes para investigacin son: Coskun et al., 2022 (Cell Metabolism): caracterizacin molecular del compuesto LY3437943, demostrando potencia comparable al GLP-1 endgeno sobre GLP-1R y actividad sustancial sobre GIP-R y GCG-R, con balance racionalmente diseado
Interestingly, U251 cell line was more sensitive to these nanoformulations (lower EC 50 comparing to U-87MG)
It has been published in the Journal of Lipid Research
Primary clear cell sarcoma of bone: a unique site of origin
We postulated that 5FU treatment may promote an enhanced dependency on mitochondrial metabolism, and, in turn, mitochondrial metabolism may dictate sensitivity to 5FU
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