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This echoes a broader challenge in the supplement industry, where individual responses vary dramatically based on baseline nutritional status, diet quality, medication dosage, and other factors

240 In glioblastoma, hepatocyte growth factor (HGF)/c-Met signaling enhances -catenin nuclear localization and LEF1-dependent transcription of MDRassociated genes such as MRP-1, inducing CSC traits, endothelialmesenchymal transition (EndMT), and temozolomide resistance

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In addition, altered functional connectivity has also been reported in the brainstem, basal ganglia and related areas such as the limbic system [123]