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Most protocols begin at 1 to 2 mg, which produces modest glucagon receptor activation
The subcutaneous injection can be given in the abdomen, thigh, or upper arm (upper arm may require assistance), with patients advised to rotate injection sites to minimize local reactions
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The compounded tirzepatide they provide uses the same active ingredient as FDA-approved Mounjaro, but compounded products themselves are not evaluated by the FDA for safety, effectiveness, or quality
To ensure optimal FcRn binding, cellular transport, and PK properties of albumin-based biologics, we attempted to substitute the C-terminal L585 of albumin with an amino acid residue that would not be recognized by CPA
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