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It inhibits ferroptosis by inhibiting the expression of activating transcription factor 3 (ATF3), reducing the levels of lipid ROS and increasing the levels of GSH, which ultimately attenuates IRI- or FA-induced AKI [190]
Mechanism [edit] Glutathione synthase catalyzes the chemical reaction ATP + gamma-L-glutamyl-L-cysteine + glycine ADP + phosphate + glutathione The 3 substrates of this enzyme are ATP, gamma-L-glutamyl-L-cysteine, and glycine, whereas its 3 products are ADP, phosphate, and glutathione
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