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8 The effects of PEG size on ADC PK and toxicity profile were determined using drug-linkers attached to a nonbinding IgG with a DAR of 8 which were examined in SpragueDawley (SD) rats after intravenous administration of 3 mg/kg of the antibody-drug conjugates reported by Burke et al 9

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The nose-to-brain transport pathway via the olfactory nerve and trigeminal nerve may deliver epitalon more efficiently to the brain regions relevant to pineal function than systemic injection, which requires BBB crossing