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Most people notice the biggest changes between weeks 5-8

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Unlike IL-8, MCP-1 is a member of the C-C chemokine family and is induced by proinflammatory stimuli such as TNF- and IFN- and by lipopolysaccharides in a variety of cell types, including fibroblasts, endothelial cells, smooth muscle cells, keratinocytes, hepatocytes, monocytes/macrophages, and lymphocytes

To confuse the matter further, the American Academy of Pediatrics appeared to have it both ways

"2019 European League Against Rheumatism/American College of Rheumatology Classification Criteria for Systemic Lupus Erythematosus"