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244247] As to dose, there are multiple considerations: Adding an appropriate supportive dose without overdosing Assuring cofactor availability Form of glutathione supplement and bioavailability My recommendations generally are to have intake of a supplement with trace elements and other minerals like magnesium, a prenatal supplying the b-vitamin cofactors, and assuring at least 200-600 IU of tocopherols (depending on form)
Very recently, genetically engineered Rhizobium-legume symbiont expressing As(III) S-adenosylmethionine methyltransferase (arsM) gene from alga Chlamydomonas reinhardtii showed methylation and subsequently volatilization of As (Zhang et al., 2017)
[Epub ahead of print] Dekok H
that broader claim is not well supported
However, further dose-response analysis and adjustment for intake of other vitamin and mineral supplements indicated that all-cause mortality risk was significantly increased by 7% only at a dose of 2,000 IU/day, which is notably higher than the UL for adults (1,100 IU/day of synthetic tocopherol or 1,500 IU/day of natural tocopherol)
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