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Thus, leveraging CSF1R blockade in conjunction with ICIs or cytokine-based therapies represents a compelling avenue for enhancing immunotherapy efficacy in ovarian cancer

Of significance is the fact that the thiazolidinedione (TZD) class of drugs used to treat the hyperglycemia of type 2 diabetes (see the next section) activate PPAR which in turn increases the level of activity of PGC-1

Clinical practice guideline for diabetes management in chronic kidney disease

As far as thyroid cancer is concerned, in vitro and in vivo studies focused on the potential anti-cancer effects of metformin and phenformin

This reinforces why diagnosis-driven selection is the most defensible approach rather than choosing supplements based on popularity or general wellness claims