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Clinical scenarios warranting consideration of GLP-1 therapy include: Type 2 diabetes management : Per ADA 2024 Standards of Care, GLP-1 RAs may be considered as initial therapy in patients with established atherosclerotic cardiovascular disease (ASCVD), high ASCVD risk, chronic kidney disease (CKD), or heart failure, or as add-on therapy when glycemic targets aren't met Established cardiovascular disease : Several GLP-1 receptor agonists have demonstrated cardiovascular risk reduction in patients with type 2 diabetes and established ASCVD Chronic kidney disease : While SGLT2 inhibitors are generally prioritized for CKD with type 2 diabetes when eGFR allows, GLP-1 RAs may provide complementary benefits Obesity with complications : When lifestyle interventions produce insufficient weight loss in patients with obesity-related comorbidities Important safety considerations include: Contraindications : Personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia syndrome type 2
Cardiovascular Benefits Recent research has uncovered that GLP drugs may also offer protective benefits for the heart
However, none are true GLP-1 agonists, and no supplement can replicate the clinical potency of semaglutide or tirzepatide
doi:10.1016/j.cgh.2018.04.034 Koloski NA, Jones M, Talley NJ
tanto es as que, de hecho, puede unirse a los receptores de insulina (aunque con una capacidad disminuida en comparacin con la propia insulina)
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