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The most important limitation on enthusiasm is safety: the dominant and consistent burden is gastrointestinal intolerance and delayed gastric emptying, which has practical implications for dose escalation and peri-procedural management (Jalleh et al., 2024), (Karagiannis et al., 2024)

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[4] On the other side, Rosenstock and colleagues, in the Lancet, showed retatrutide delivering strong glycemic control and big weight loss in people with type 2 diabetes, beating tirzepatide at similar doses in the efficacy comparison

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