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In OA and other chronic degenerative disorders, cells and tissues also undergo shifts in energy metabolism and biosynthetic pathways to adapt to pathological microenvironments characterized by hypoxia, inflammation, mechanical stress, and nutrient limitation (6163)
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Microbial metabolites such as SCFAs and tryptophan catabolites can influence brain function directly or via modulation of systemic inflammation
The protection was evidenced by improved cell viability, a systematic downregulation of pro-inflammatory cytokines, enhanced activity of antioxidant enzymes, and a modulated balance of apoptosis-related proteins
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