The current picture is mechanistically credible and supported by small-scale human data, not clinically definitive
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Severe deficiency : Weekly or biweekly injections may initially be required to correct anemia and neurological symptoms
In particular, the interaction of ROS with NO, which is the best characterized (and likely most important) mediator of endothelial function, is felt to have an important role in determining the causal relationship between oxidative stress and hypertension