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They are at their highest during the day when your cells are under the most stress from movement, light exposure, and mental tasks

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[2] Sun X, Deng Y, Fu X, Wang S, Duan R, Zhang Y

Improved gut inflammation often comorbid with fibromyalgia

That uncertainty is precisely why it remains an interesting research tool rather than a settled one, and it is stated plainly here rather than papered over with confident mechanism claims