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The effectiveness of glutathione depends on its state within the cell
Future Med Chem
In the kidneys with TLS, Gpx4 expression was modestly decreased, while Acsl4 expression was increased compared with controls, consistent with ferroptosis-associated changes (Supplemental Figure 13)
One possibility is that direct GCL inhibition leads to upregulation of an alternative antioxidant pathway that can maintain cell survival in the absence of GSH
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