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World Health Organization, NCBI Bookshelf
Low Vitamin B12 levels may be related to dietary patterns, age-related absorption changes, digestive conditions, certain medications, autoimmune conditions such as pernicious anemia, or limited intake of animal-based foods
In a randomized controlled trial, increased physical activity consisting of leg exercises and walking significantly improved wound healing in patients with venous leg ulcers (Heinen 2012)
Like other copper-binding tripeptides, its biological effects are proposed to occur through both the peptide backbone and the copper ion it coordinates with the copper contributing to enzymatic cofactor activity and oxidative stress modulation
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