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The decreased expression of AXIN1 suppresses -catenin phosphorylation, enhancing the transcription of c-Myc and Cyclin D1
Selenium thus contributes to cell protection
It is likely that the larger number of statistically significant changes to the microbiome observed in the groups switched from WD to LD reflects their more numerous exposures to different diets, longitudinal changes in dietary exposure, the stress associated with diet switch, the negative energy state achieved by treatment and/or diet-driven weight loss, or a combination of these factors, but it may also be related to differences in terminal body weight and fat mass since both adiposity and diet composition have been shown to modulate the mouse gut microbiome profile
Dietary Restrictions: To optimize the benefits of AOD9604, participants will receive detailed dietary restrictions
29(2): S238244.CrossRefGoogle ScholarPubMed Greenberg, J, Bell, S, Guan, Y et al
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