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The Phase 3 TRIUMPH-4 readout showed 28.7% weight loss at 68 weeks exceeding both semaglutide (~14.9%) and tirzepatide (~22.5%) in their respective pivotal trials

Manifestations of oxidative stress have also been reported in the hippocampus and temporal cortex of ASD patients [119, 120]

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Separately, Ipamorelin was characterized as the first selective growth hormone secretagogue, distinguishing it from earlier GHRPs by its lack of effect on cortisol and prolactin (Raun et al., Eur J Endocrinol, 1998)