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Berthold Pemp: declares no conflict of interest relevant to this study

Long-term GH elevation also carries theoretical cancer concerns, as GH and IGF-1 can promote cell growth

Modifications of active site thiol groups by two redox-dependent aberrant post-translational modifications, S-glutathionylation and S-nitrosylation, lead to inactivation of the normal enzymatic activity of PDI (Walker et al., 2010)