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For drug release, the response of MOFs to stimulation is strong

However, like any medication, it can cause side effects in some patients

Nausea, which affected 18-36% of participants at the 4 mg dose and 17-60% at the 8 mg dose in clinical trials, usually peaks during the first week of each new dose level and then subsides as the body adapts

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However, meaningful, clinically significant weight loss typically defined as 5% of baseline body weight, a threshold referenced in NICE guidance on the management of overweight and obesity generally becomes apparent between weeks 8 and 12 , particularly as the dose is gradually escalated according to the trial protocol