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Untargeted lipidomics analysis of synovial fluid and serum from RA patients across various clinical stages, ranging from preclinical to active and sustained phases, showed that despite normal erythrocyte sedimentation rate and CRP at pre-clinical stages, the lipidomic profile of preclinical RA joint fluid closely resembled that of active RA (191)

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We upregulated the expression of GCLC, GSS, or SLC7A11 in VRK2-KD PC cells, and investigated the effects of these genes on cell viability, ROS and GSH levels when provided exogenous ROS ter-tbutyl hydroperoxide (TBHP)