Activation of GLP-1R induces an increase in intracellular Ca 2+ in 40% of NTS astrocytes, while selective inhibition of astrocyte function in NTS abolishes exendin-4-induced inhibition of food intake (Reiner et al., 2016)
McBride encourages providers who feel confident managing obesity in primary care to be strategic and proactive in both diagnosing and escalating care
However, they should not fully replace whole foods long term, as they may lack some beneficial nutrients and plant compounds found in fruits and vegetables
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If you observe any of these, the solution should be discarded immediately, without question