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Haematologica 102(1):e26 Gemel J, Mao Y, Lapping-Carr G, Beyer EC (2020) Gap junctions between endothelial cells are disrupted by circulating extracellular vesicles from sickle cell patients with acute chest syndrome

Furthermore, BEC is a slow-binding inhibitor of arginase, which is still in the preclinical stage (Pudlo et al., 2017)

Notably, size-dependent transport was observed in animal models where smaller or functionalized NPs resulted in a higher accumulation and release of the payload in the targeted area (Cruz et al., 2016)

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