For short-acting peptides such as Sermorelin (t ~1120 min), Tesamorelin (t ~26 min), and AOD-9604 (t ~30 min), pulsatile administration once or twice daily is the predominant research approach
Reduced endothelial and smooth muscle proliferation in association with MMF have also been proposed as a possible mechanism, although the evidence is more limited than for mTOR inhibitors (190)
& Mongiardo, K
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All GLP-1s have the potential to cause nausea, vomiting, diarrhea, and other severe GI issues, pancreatitis, headache, dizziness, hypersensitivity and anaphylaxis, and injection site pain