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Collectively, these results suggested that EV-derived VDAC1 protein is a potential therapeutic target for averting PTX resistance of GC and a specific inhibitor of VDAC1, such as DIDS, might serve as a component of combination therapy to overcome PTX resistance

In addition to serving as a channel for amino acids to enter and exit the cell, AATs also function as a probe for sensing amino acid levels and as an initiator of nutritional signals

For researchers and clinicians, this means making decisions based on incomplete information

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