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The present study provides preliminary evidence in favor of the GLP-1 based therapies in providing beneficial effects against atherosclerosis as indicated by the significant reductions in atherosclerosis markers including BNP, PAI-1 and hsCRP, besides statistically non-significant reductions in several other markers including IMT, FMD, IL-6 and TNF- were also noted
PMID 18709888
Additionally, weight regain while maintaining consistent dosing warrants evaluation for underlying causes or treatment modifications
M.GoulartM
The pivotal role of DPP-4 in endogenous GLP-1 metabolism was highlighted using the isolated perfused porcine small intestine, which revealed that over half of newly released GLP-1 was degraded even before it left the splanchnic bed
