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The FLOW trial demonstrated meaningful reductions in kidney disease progression with semaglutide. The SELECT trial showed a 20% reduction in major adverse cardiovascular events in patients with obesity and established cardiovascular disease. These are not trivial findings

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Growth hormone and IGF-1 are involved in muscle protein synthesis, fat oxidation, and tissue repair, so it is reasonable that restoring more youthful GH signaling could influence those areas

Glutazumab Glutazumab ( Gmax Biopharm ) is a novel antibody-drug that targets GLP-1R directly