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Other GLP-1 Medications: Less Common Alternatives: Liraglutide (Saxenda): Daily injection (not weekly) Less effective than semaglutide or tirzepatide Average 5-8% weight loss More expensive than newer options Rarely recommended now that better options exist Dulaglutide (Trulicity): Weekly injection Primarily for diabetes, not weight loss Less effective for weight loss than semaglutide/tirzepatide Not typically prescribed for weight loss These older medications have largely been superseded by more effective semaglutide and tirzepatide options

Its most effective when combined with sustainable lifestyle changes and ongoing medical supervision

Acute kidney injury : Though rare, any GLP-1 receptor agonist can potentially cause dehydration (particularly if severe vomiting or diarrhoea occurs), which may precipitate kidney problems

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On the other hand, taste-related complaints frequently co-occur with gastrointestinal symptoms such as nausea and early satiety (35, 68), making it difficult to distinguish between objective gustatory dysfunction (sensory) and reward revaluation driven by state-related signals (liking/wanting) at the clinical level