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This could relate to different pharmacokinetic profiles, lower peak drug levels, or differences in how the oral versus injectable forms interact with the nervous system

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Methods GLP-1 agonists included in the analysis were approved for treatment of obesity (Saxenda, Wegovy, Zepbound) and corresponding formulations that may potentially be used off-label for treatment of obesity (Mounjaro, Ozempic, Rybelsus, Victoza)