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The GH response to secretagogues is saturable: beyond a certain point, additional GHRP-2 does not produce proportionally more GH because the pituitarys releasable pool and the receptor system are finite, and somatostatin feedback increasingly opposes release

The phase 3 TRIUMPH-4 data showed these rates at 9 mg and 12 mg doses respectively: Nausea: 38.1% and 43.2% (vs 10.7% placebo) Diarrhea: 34.7% and 33.1% (vs 13.4% placebo) Constipation: 21.8% and 25.0% (vs 8.7% placebo) Vomiting: 20.4% and 20.9% (vs placebo) These numbers are higher than cagrilintide monotherapy across the board

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Int J Immunopathol Pharmacol