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[published online ahead of print, 2022 Apr 20]
These enzymes function as multi-subunit complexes, where the catalytic activity is provided by the SET domain within the MLL proteins located near the C -terminus for their intrinsic methyltransferase activity, which is weak in the absence of the core subunits (WDR5, RBBP5, ASH2L, and DPY30) (Ruthenburg et al., 2007)
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The products of the -oxidation are then used by the Krebs cycle to produce adenosine triphosphate (ATP) as a form of energy [7]
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