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A Mayo Clinic study found postmenopausal women using hormone therapy alongside tirzepatide (a GLP-1/GIP dual agonist) experienced notably greater weight loss compared with those using tirzepatide without HRT
J Inherit.Metab Dis 1-7-2008
This may be because the anti-seizure effects reduced glucose availability and suppressed sodium transport across neuronal membranes, thereby conferring a stabilizing effect against abnormal depolarization
The new Wegovy 7.2mg dose was licensed for use in the UK in January 2026
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